Our goal is to apply basic science discoveries in the laboratory in order to benefit human health in newborns, adults, and elderly. To achieve these aims, we utilize cutting edge tools and robust models of clinically relevant disease. Because diabetes and cancer currently represent two of the largest healthcare burdens and leading causes of death in the United States, our current projects seek to understand the immunoregulatory networks involved during cancer and obesity. Furthermore, human cytomegalovirus (HCMV) represents the most common congenital infection associated with birth defects in the United States. Our current projects will determine the mechanisms that promote memory formation in the immune system to develop novel vaccination strategies for HCMV. Understanding the precise cellular and molecular mechanisms used by the immune system to prevent or promote pathology in these contexts will create potential therapies for the treatment of cancer, type II diabetes, and HCMV.
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