The O'Sullivan Lab has pioneered an interdisciplinary approach to unlock the full potential of the human innate immune system. By integrating cutting-edge systems biology with advanced CRISPR editing in primary human immune cells, we have identified critical gene targets and mechanisms underlying the protective and pathologic functions of the innate immune system. Our mission is to discover novel therapeutic strategies and engineer innate immune function to combat major global health challenges, including cancer and infectious diseases.
We have focused on 3 major research areas:
